Saliva plays a critical role in oral lubrication by coating oral surfaces with a highly hydrated, proteinaceous film with a complex layer structure[1]. The interaction between this salivary film and the ingredients of foods, beverages, and oral care products is hypothesised to influence their sensory perception. Here we focus on the tribological impact arising from interactions between dairy and salivary proteins that are pre-adsorbed to hydrophobic substrates. We explore the effect of dairy proteins on the lubricity of saliva films using our dynamic tribological protocol (DTP)[2], in combination with surface film characterisation and sensory mouthfeel studies. While previous tribological studies with saliva primarily focus on its relevance to astringency perception (tea, wine, and dairy), the solutions studied here are not considered astringent.
In the DTP method, an ex vivo saliva pellicle is formed by adsorbing acid-stimulated human whole saliva onto hydrophobic elastic substrates. Once adsorbed, lubricity is measured before and after exposure to skim milk and whey protein isolate (WPI) mixtures with varying casein to whey protein (C:W) ratios under neutral pH conditions. Trained sensory panellists performed descriptive sensory analysis on the samples. The lubricity of the saliva pellicle decreased upon contact with dairy solutions, with greater decreases corresponding to higher C:W ratios. Friction parameters from DTP are strongly correlated with in-mouth textural attributes such as thickness and smoothness, and after-feel attributes mouth coating and smoothness. The correlation between sensory texture perception and the friction coefficient for samples measured with DTP is significantly higher than the friction coefficient measured with samples alone or viscosity measurements.
To investigate the mechanism driving the decrease in lubricity with an increase in casein content we used surface characterization techniques, such as quartz crystal microbalance with dissipation (QCM-D), atomic force microscopy (AFM), and scanning electron microscopy (SEM)[3]. Our findings indicate that an increase in casein content increases the mass loss from the salivary pellicle. Interaction with whey protein softens the pellicle, whereas exposure to micellar casein causes the pellicle to partially collapse, resulting in a thinner and more rigid layer. These structural changes correlate with lubrication behaviour. Our study highlights the importance of casein-saliva interactions.
This study demonstrates that the saliva-dairy protein interactions play a key role in influencing the structural and lubrication properties of the saliva pellicle. The DTP with saliva-coated substrates offers rich information about oral processes and provides relevant insights into texture and mouthfeel perception during and after the consumption of dairy systems. This knowledge provides insights into how different dairy food and beverage components contribute to mouthfeel, texture perception, and oral hygiene.
Reference:
1. Yakubov, G., et al., Aqueous lubrication by fractionated salivary proteins: Synergistic interaction of mucin polymer brush with low molecular weight macromolecules. Tribology International, 2015. 89: p. 34-45.
2. Fan, N., et al., Dynamic Tribology Protocol (DTP): Response of salivary pellicle to dairy protein interactions validated against sensory perception. Food hydrocolloids, 2021. 113.
3. Fan, N., et al., Structure Response of Preadsorbed Saliva Pellicle to the Interaction between Dairy and Saliva Protein. Langmuir, 2024. 40(22): p. 11516-1152